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SB-269970 (hydrochloride)

SB-269970 (hydrochloride)

Item no.	HY-15370A-10mM
Manufacturer	MedChem Express
CASRN	261901-57-9
Amount	10 mM/1 mL
Quantity options	10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Purity	98.62
Citations	[1]http://www.ncbi.nlm.nih.gov/pubmed/10821781\|[2]Roberts C, et al. The effect of SB-269970, a 5-HT(7) receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies. Br J Pharmacol. 2001 Apr;132(7):1574-80.\|[3]Monti JM, et al. The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat. Behav Brain Res. 2008 Aug 22;191(2):184-9. Authorea. September 19, 2022.\|Cancer Lett. 2024 Aug 1:217150.\|Int J Biol Sci. 2024 Aug 19;20(11):4476-4495.\|Protein Cell. 2019 Mar;10(3):178-195.
Smiles	OC1=CC=CC(S(=O)(N2[C@@H](CCN3CCC(C)CC3)CCC2)=O)=C1.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SB-269970A
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	5-HT Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	388.95
Product Description	SB-269970 hydrochloride is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 hydrochloride exhibits >50-fold selectivity against other 5-HT receptors[1][2].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: ≥ 30 mg/mL\|H2O: 10 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	5-HT7 Receptor; MUC3
Clinical information	No Development Reported

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HY-15370A-10mM-safety-datasheet.pdf