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ML-7 (hydrochloride)

ML-7 (hydrochloride)

Item no.	HY-15417-50mg
Manufacturer	MedChem Express
CASRN	110448-33-4
Amount	50 mg
Quantity options	10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.88
Citations	[1]Shi J, et al. Myosin light chain kinase-independent inhibition by ML-9 of murine TRPC6 channels expressed in HEK293cells. Br J Pharmacol. 2007 Sep;152(1):122-31.\|[2]Yu J, et al. Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation. Int J Med Sci. 2015 Sep 4;12(9):727-36\|[3]Luh C, et al. Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury. J Neurochem. 2010 Feb;112(4):1015-25.\|[4]Pobbati AV, et, al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. 2020 Feb 18;10(8):3622-3635.
Smiles	O=S(N1CCNCCC1)(C2=C3C=CC=C(I)C3=CC=C2)=O.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	110448-33-4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Myosin; YAP
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	452.74
Product Description	ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK (IC50=300 nM). ML-7 hydrochloride also inhibits YAP/TAZ.
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 43 mg/mL\|H2O: 1.43 mg/mL (ultrasonic)
Manufacturer - Pathway	Cytoskeleton; Stem Cell/Wnt
Isoform	YAP/TAZ
Clinical information	No Development Reported

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HY-15417-50mg-safety-datasheet.pdf