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PF-543 (Citrate)

PF-543 (Citrate)

Item no.	HY-15425A-10mg
Manufacturer	MedChem Express
CASRN	1415562-83-2
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.47
Citations	[1]Schnute ME, et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88.\|[2]MacRitchie N, et al. Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cell Signal. 2016 Aug;28(8):946-55.\|[3]Hamada M, et al. Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells. Cell Death Discov. 2017 Aug 14;3:17047. Mol Cell. 2020 Mar 19;77(6):1294-1306.e5. \|Cancer Sci. 2020 Jul;111(7):2259-2274.\|Cell Death Dis. 2024 Aug 1;15(8):552.\|Curr Res Pharmacol Drug Discov. 2025 Jan 9.\|Hum Cell. 2020 Jan;33(1):57-66.\|Inflammation. 2021 Dec;44(6):2170-2179.\|Pflugers Arch. 2025 Feb 3.\|Sci China Life Sci. 2021 May 27;1-21.\|Sci Rep. 2020 Aug 14;10(1):13834.\|FASEB J. 2024 Jan 31;38(2):e23417.
Smiles	OC(C(O)=O)(CC(O)=O)CC(O)=O.O=S(C1=CC=CC=C1)(CC2=CC(C)=CC(OCC3=CC=C(CN4[C@@H](CO)CCC4)C=C3)=C2)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Sphingosine Kinase 1 Inhibitor II (Citrate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; Autophagy; LPL Receptor; SphK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	657.73
Product Description	PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy[1][2][3].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Cardiovascular Disease
Solubility	DMSO: 200 mg/mL (ultrasonic)\|H2O: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation
Isoform	SphK1
Clinical information	No Development Reported

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HY-15425A-10mg-safety-datasheet.pdf