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MLN120B

MLN120B

Item no.	HY-15473-10mg
Manufacturer	MedChem Express
CASRN	783348-36-7
Amount	10 mg
Quantity options	10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules By Organ Lymphatic System Cancer Oligodendrocyte Markers
Type	Inhibitors
Specific against	other
Purity	99.76
Formula	C19H15ClN4O2
Citations	[1]Hideshima T, et all. MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. Clin Cancer Res. 2006 Oct 1;12(19):5887-94. [2]Schopf L, et al. IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis. Arthritis Rheum. 2006 Oct;54(10):3163-73. [3]Ansaldi D, et al. Imaging pulmonary NF-kappaB activation and therapeutic effects of MLN120B and TDZD-8. PLoS One. 2011;6(9):e25093. [4]Nagashima K, et al. Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta. Blood. 2006 Jun 1;107(11):4266-73.
Smiles	O=C(C1=CC=CN=C1C)NC2=C(OC)C(Cl)=CC3=C2NC4=C3C=CN=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ML120B
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	IKK
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	366.80
Product Description	MLN120B (ML120B) is a potent, ATP competitive, and orally active inhibitor of IKKβ with an?IC50?of 60 nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rheumatoid arthritis[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO : ≥ 31 mg/mL
Manufacturer - Pathway	NF-κB
Isoform	IKK-β
Clinical information	No Development Reported

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HY-15473-10mg-safety-datasheet.pdf