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RGB-286638

RGB-286638

Manufacturer	MedChem Express
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Amount	5 mg
Item no.	HY-15504-5mg
Targets	CDK; GSK-3; MEK; JAK
CASRN	784210-87-3
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	618.55
Clinical_Information	Phase 1
Manufacturers Research_Area	Cancer
Solubility	DMSO : ≥ 150 mg/mL\|H2O : 25 mg/mL (ultrasonic)
Manufacturers Target	CDK; GSK-3; JAK; MEK
Isoform	CDK1; CDK2; CDK3; CDK4; CDK5; CDK6; CDK7; CDK9; GSK-3β; JAK2; MEK1
Pathway	Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-15504-5mg-safety-datasheet.pdf