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INT-777 (R-enantiomer)

INT-777 (R-enantiomer)

Item no.	HY-15677A-10mM
Manufacturer	MedChem Express
CASRN	1198786-98-9
Amount	10mM/1mL
Quantity options	10mM/1mL 2 mg 5 mg
Category	Metabolism Cholesterol & Lipid Metabolism Lipoprotein Receptors & Associated Proteins Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.73
Citations	[1]Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.
Smiles	O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](CC)[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@H](C)C[C@@H](C)C(O)=O)([H])C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	S-EMCA R enantiomer
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Targets	G protein-coupled Bile Acid Receptor 1
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	450.65
Product Description	INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.
Manufacturer - Research Area	Others
Solubility	DMSO : ≥ 100 mg/mL
Manufacturer - Pathway	GPCR/G Protein
Clinical information	No Development Reported

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HY-15677A-10mM-safety-datasheet.pdf