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Epacadostat

Epacadostat

Item no.	HY-15689-50mg
Manufacturer	MedChem Express
CASRN	1204669-58-8
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 g 1 mg 200 mg 25 mg 2 g 500 mg 50 mg 5 mg
Category	Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Lipoprotein Receptors & Associated Proteins Lipid & Fatty Acid Transport Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.66
Formula	C11H13BrFN7O4S
Citations	[1]Liu X, et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood. 2010 Apr 29;115(17):3520-30. [2]Koblish HK, et al. Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors. Mol Cancer Ther. 2010 Feb;9(2):489-98. [3]Fu R, et al. LW106, a novel indoleamine 2,3-dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma-immune crosstalk and cancer stem cell enrichment in tumour micro-environment. Br J Pharmacol. 2018 Jul;175(14):3034-3049.
Smiles	BrC1=C(F)C=CC(N/C(C2=NON=C2NCCNS(N)(=O)=O)=N\O)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	INCB 024360
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Indoleamine 2, 3-Dioxygenase (IDO)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	438.23
Product Description	Epacadostat (INCB 024360) is a potent and selective indoleamine 2, 3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM[1].
Manufacturer - Research Area	Inflammation/Immunology; Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Isoform	IDO1
Clinical information	Phase 3

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HY-15689-50mg-safety-datasheet.pdf