NS6180

Item no.	HY-15707-10mM
Manufacturer	MedChem Express
CASRN	353262-04-1
Amount	10 mM/1 mL
Quantity options	10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer
Type	Inhibitors
Specific against	other
Purity	99.76
Citations	[1]Strobak D, et al. NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Br J Pharmacol. 2013 Jan;168(2):432-44.
Smiles	O=C1CSC2=CC=CC=C2N1CC3=CC=CC(C(F)(F)F)=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	353262-04-1
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Potassium Channel
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	323.339
Product Description	NS6180 is a new orally active KCa3.1 channel inhibitor. NS6180 inhibits cloned human KCa3.1 channels with an IC50value of 9 nM. NS6180 can be used for the research of inflammatory bowel disease (IBD) [1].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: ≥ 100 mg/mL
Manufacturer - Pathway	Membrane Transporter/Ion Channel
Clinical information	No Development Reported

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HY-15707-10mM-safety-datasheet.pdf