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Istaroxime

Istaroxime

Item no.	HY-15718-10mg
Manufacturer	MedChem Express
CASRN	203737-93-3
Amount	10 mg
Quantity options	100 mg 10 mg 1 ea 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	Pnas nexus . 2023 Dec 22. Biochem Pharmacol. 2020 Oct;180:114122. Biochem Pharmacol. 2023 Mar 24;211:115516. Front Pharmacol. 2020 Dec 14. J Am Heart Assoc. 2021 Jul 3;e018833. [1]Gobbini M, et al. Novel analogues of istaroxime, a potent inhibitor of Na+,K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51(15):4601-8. [2]Gobbini M, et al. Novel analogues of Istaroxime, a potent inhibitor of Na(+),K(+)-ATPase: Synthesis, structure-activity relationship and 3D-quantitative structure-activity relationship of derivatives at position 6 on the androstane scaffold. Bioorg Med Ch [3]Micheletti R, et al. Pharmacological profile of the novel inotropic agent (E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744). J Pharmacol Exp Ther. 2002 Nov;303(2):592-600.
Smiles	O=C1CC[C@@]2([H])[C@]3([H])CC([C@@]4([H])C/C(CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=N/OCCN)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PST2744
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Na+/K+ ATPase
Shipping Temperature	Room temperature
Molecular Weight	360.49
Product Description	Istaroxime (PST2744) is a potent inhibitor of Na+, K+-ATPase with IC50 of 0.11 μM.
Manufacturer - Research Area	Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Membrane Transporter/Ion Channel
Clinical information	Phase 2

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Amount: 10 mg

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