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A 419259 (trihydrochloride)

A 419259 (trihydrochloride)

Item no.	HY-15764A-50mg
Manufacturer	MedChem Express
CASRN	1435934-25-0
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	99.21
Citations	[1]Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21(53):8075-88.\|[2]Zhang X, et al. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13(3 Pt A):379-89. Blood. 2016 Jun 23;127(25):3237-52.\|Blood. 2016 Jun 23;127(25):3237-52.\|J Med Chem. 2024 Nov 28;67(22):20571-20579.\|Microb Pathog. 2024 Dec 25:199:107252.\|Patent. US20170333436A1.
Smiles	NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1.[H]Cl.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	RK 20449 trihydrochloride
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; Src
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	592.00
Product Description	A 419259 trihydrochloride is a Src family kinases inhibitor with IC50s of 9 nM, 3 nM and 3 nM for Src, Lck and Lyn, respectively[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 1 mg/mL (ultrasonic)\|H2O: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Protein Tyrosine Kinase/RTK
Clinical information	No Development Reported

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HY-15764A-50mg-safety-datasheet.pdf