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UNC2250

UNC2250

Item no.	HY-15797-50mg
Manufacturer	MedChem Express
CASRN	1493694-70-4
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bladder Cancer Colorectal Cancer
Type	Inhibitors
Specific against	other
Purity	99.92
Citations	[1]Zhang, W., et al., Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J Med Chem, 2013. 56(23): p. 9683-92.\|[2]Xiaodong Wang, et al. Pyrimidine compounds for the treatment of cancer.WO2013177168A1.
Smiles	CCCCNC1=NC(N[C@@H]2CC[C@@H](O)CC2)=C(C3=CC=C(CN4CCOCC4)C=N3)C=N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1493694-70-4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	TAM Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	440.58
Product Description	UNC2250 is a potent and selective Mer inhibitor with an IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.
Manufacturer - Research Area	Cancer
Solubility	0.1 M HCl: 12.5 mg/mL (ultrasonic; adjust pH to 3 with HCl)\|DMSO: ≥ 10 mg/mL
Manufacturer - Pathway	Protein Tyrosine Kinase/RTK
Isoform	Axl; Mer
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-15797-50mg-safety-datasheet.pdf