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Ravoxertinib hydrochloride

Ravoxertinib hydrochloride

Item no.	HY-15947A-50mg
Manufacturer	MedChem Express
CASRN	2070009-58-2
Amount	50 mg
Quantity options	10 mM/1 mL 10 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Colorectal Cancer
Type	Inhibitors
Specific against	other
Purity	99.44
Citations	[1]Blake JF, et al. Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Developme\|[2]Kirk Robarge, et al. Abstract DDT02-03: Discovery of GDC-0994, a potent and selective ERK1/2 inhibitor in early clinical development. Proceedings: AACR Annual Meeting 2014; April 5-9, 2014.\|[3]MICHAEL LAI. Opportunity for Pharmaceutical Intervention in Lung Cancer: Selective Inhibition of JAK1/2 to Eliminate EMT-Derived Mesenchymal Cells. ACS Omega. 2023 May 23.\|Nucleic Acids Res. 2022 Apr 8;50(6):3096-3114.\|Pathol Res Pract. December 2021, 153682.\|ACS Comb Sci. 2019 Dec 9;21(12):805-816.\|Am J Cancer Res. 2020 Nov 1;10(11):3622-3643.\|Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H580-H592.\|Biochem Biophys Res Commun. 2021 Mar 26;554:63-70.\|Cancer Cell. 2023 Jul 10;41(7):1345-1362.e9.\|Cancer. 2020 Mar 15;126(6):1339-1350.\|Cancers (Basel). 2022 Mar 19;14(6):1575.\|Cancers (Basel). 2022 May 19;14(10):2493.\|Cell Death Dis. 2021 Dec 1;12(12):1123.\|Cell Mol Immunol. 2023 Jan 5.\|Cell Rep Med. 2025 Feb 6:101970.\|Cell Rep. 2023 Sep 1;42(9):113048.\|Cell Signal. 2023 Jan 20;110607.\|Cell. 2018 Sep 20;175(1):186-199.e19.\|Clin Transl Med. 2023 Aug;13(8):e1381.\|Diabetes. 2021 Jun 21;db200719.\|Environ Pollut. 2021 Jan 1;268(Pt B):115748.\|Exp Mol Pathol. 2021 Feb;118:104587.\|Gastric Cancer. 2023 Feb 22.\|Harvard Medical School LINCS LIBRARY\|Indian J Pharm Sci. 2022.\|Int J Med Sci. 2022 Jan 1;19(1):195-204.\|iScience. 2024 Sep 12;27(10):110873.\|J Cell Biochem. 2020 Mar;121(3):2343-2353.\|J Cell Mol Med. 2020 Sep;24(17):10151-10165.\|J Exp Clin Cancer Res. 2023 Jul 13;42(1):166.\|J Pharmacol Exp Ther. 2020 Jul;374(1):104-112.\|Methods Mol Biol. 2018;1711:351-398.\|Mol Oncol. 2020 Nov;14(11):2894-2919.\|Nat Commun. 2023 Sep 30;14(1):6117.\|Nat Metab. 2022 Mar;4(3):374-388.\|Nature. 2025 Jan;637(8046):726-735. \|Neural Regen Res. 2023.\|Oncogene. 2021 Jul;40(30):4884-4893.\|Proteomics. 2023 May 4;e2300041.\|Redox Biol. 2023 Jul 24, 102825.\|Reprod Sci. 2020 Feb;27(2):704-712.\|Sci Transl Med. 2021 Jan 27;13(578):eaba7308.\|Toxicol In Vitro. 2020 Jun;65:104777.\|Universität Würzburg. Graduate School of Life Sciences. 2021 Jan.\|Université de Lausanne. 2024 Feb 7.\|Zool Res. 2022 Jul 18;43(4):537-551.
Smiles	O=C1C=C(C2=NC(NC3=CC=NN3C)=NC=C2)C=CN1[C@@H](C4=CC=C(Cl)C(F)=C4)CO.Cl[H]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GDC-0994 (hydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	ERK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	477.32
Product Description	Ravoxertinib hydrochloride (GDC-0994 hydrochloride) is an orally bioavailable inhibitor selective for ERK kinase activity with IC50 of 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)
Manufacturer - Pathway	MAPK/ERK Pathway; Stem Cell/Wnt
Isoform	ERK1; ERK2
Clinical information	Phase 1

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HY-15947A-50mg-safety-datasheet.pdf