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ENMD-1198

ENMD-1198

Item no.	HY-16196-1mg
Manufacturer	MedChem Express
CASRN	864668-87-1
Amount	1 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 20 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.87
Citations	[1]Pasquier E, et al. ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties. Mol Cancer Ther. 2010 May;9(5):1408-18.\|[2]Snoeks TJ, et al. 2-methoxyestradiol analogue ENMD-1198 reduces breast cancer-induced osteolysis and tumor burden both in vitro and in vivo. Mol Cancer Ther. 2011 May;10(5):874-82.\|[3]Moser C, et al. ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo. BMC Cancer. 2008 Jul 23;8:206.
Smiles	C[C@@]12C=CC[C@@]1([H])[C@]3([H])CCC4=C(C=C(OC)C(C(N)=O)=C4)[C@@]3([H])CC2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	IRC-110160
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	HIF/HIF Prolyl-Hydroxylase; Microtubule/Tubulin; STAT
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	311.42
Product Description	ENMD-1198 (IRC-110160), an orally active microtubule destabilizing agent, is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity. ENMD-1198 is suitable for inhibiting HIF-1alpha and STAT3 in human HCC cells and leads to reduced tumor growth and vascularization.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt
Isoform	STAT3
Clinical information	Phase 1

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HY-16196-1mg-safety-datasheet.pdf