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Forodesine

Forodesine

Item no.	HY-16210-2500ug
Manufacturer	MedChem Express
CASRN	209799-67-7
Amount	2500 ug
Quantity options	10 mM/1 mL 10 mg 1 mg 2500 ug 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	99.10
Citations	[1]Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895.\|[2]Bantia S, et al. Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent. Int Immunopharmacol. 2001 Jun;1(6):1199-210. Cell Metab. 2024 Sep 28:S1550-4131(24)00366-8.\|Chem Sci. 2024 Mar 4.\|Int J Biol Sci. 2023; 19(3):772-788.\|J Med Chem. 2023 May 3.\|Nat Commun. 2017 Aug 14;8(1):241. \|Plant J. 2023 Dec 4.\|SSRN. 2024 Mar 14.\|bioRxiv. 2019 Oct. \|Biosens Bioelectron. 2020 Dec 1;169:112616.\|Cell Rep. 2020 May 12;31(6):107640.\|Cell. 2019 Oct 31;179(4):864-879.e19.\|J Biol Chem. 2022 May;298(5):101876.\|Nat Metab. 2020 Jul;2(7):635-647.\|Neurochem Res. 2024 Nov 16;50(1):13.\|Nucleic Acids Res. 2020 Sep 25;48(17):e101.
Smiles	O=C1C(NC=C2[C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)=C2NC=N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BCX-1777,Immucillin-H
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Nucleoside Antimetabolite/Analog
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	266.25
Product Description	Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Cell Cycle/DNA Damage
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-16210-2500ug-safety-datasheet.pdf