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Kartogenin

Kartogenin

Manufacturer	MedChem Express
Category	Oncology Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Head & Neck Cancer Gastric Cancer
Type	Inhibitors
Specific against	other
Clone	N/A
Amount	10mM/1mL
Item no.	HY-16268-10mM
Targets	TGF-beta/Smad
CASRN	4727-31-5
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	Kartogenin (KGN) is an inducer of differentiation of human mesenchymal stem cells into chondrocytes, with an EC50 of 100 nM. Kartogenin binds filamin A, disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program. Kartogenin can be used for the research of osteoarthritis (OA)[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
MolecularWeight	317.34
Clinical_Information	No Development Reported
Manufacturers Research_Area	Inflammation/Immunology
Solubility	DMSO : ≥ 42 mg/mL\|H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	TGF-beta/Smad
Pathway	Stem Cell/Wnt; TGF-beta/Smad
Manufacturers Product type	Reference compound

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HY-16268-10mM-safety-datasheet.pdf