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Omtriptolide

Omtriptolide

Item no.	HY-16363-10mg
Manufacturer	MedChem Express
CASRN	195883-06-8
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 25 mg 5 mg
Category	Oncology Neuroscience Metabolism Diabetes Aging & Neurological Disorders Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	97.02
Citations	[1]Kim HJ, et al. The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2014 Jun;349(3):518-25.\|[2]Leonard CT, et al. PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model. J Heart Lung Transplant. 2002 Dec;21(12):1314-8.\|[3]Krishna G, et al. PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis. Am J Pathol. 2001 Mar;158(3):997-1004.\|[4]Chen BJ, et al. Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. Transplantation. 2000 Nov 27;70(10):1442-7.
Smiles	C[C@@]([C@@]1([H])C[C@@H]2O3)(CCC4=C1COC4=O)[C@]5([C@H]([C@H]6[C@]7(C(C)C)O6)O5)[C@]23[C@@H]7OC(CCC(O)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	195883-06-8
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	ERK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, stored under nitrogen)
Molecular Weight	460.47
Product Description	Omtriptolide (PG490-88) is a derivative proagent of triptolide purified from the Chinese herb.
Manufacturer - Research Area	Inflammation/Immunology
Solubility	H2O: 1.39 mg/mL (ultrasonic)
Manufacturer - Pathway	MAPK/ERK Pathway; Stem Cell/Wnt
Isoform	ERK
Clinical information	No Development Reported

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HY-16363-10mg-safety-datasheet.pdf