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Sonidegib

Sonidegib

Item no.	HY-16582A-10mM
Manufacturer	MedChem Express
CASRN	956697-53-3
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Heart & Blood Cancer Bone Cancer
Type	Inhibitors
Specific against	other
Purity	99.94
Citations	[1]Pan S, et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med Chem Lett. 2010 Mar 16;1(3):130-4.\|[2]Irvine DA, et al. Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Sci Rep. 2016 May 9;6:25476. bioRxiv. 2023 Nov 6.\|bioRxiv. 2024 Jul 25.\|bioRxiv. 2024 Oct 9:2024.10.08.617155.\|Cell Physiol Biochem. 2018;47(4):1352-1364.\|Tissue Cell. 2024 Nov 28:92:102643.\|J Genet Genomics. 2018 May 20;45(5):237-246.\|Nat Med. 2018 Nov;24(11):1752-1761. \|Patent. US20180263995A1.
Smiles	O=C(C1=C(C)C(C(C=C2)=CC=C2OC(F)(F)F)=CC=C1)NC3=CC=C(N=C3)N4C[C@@H](C)O[C@@H](C)C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Erismodegib,LDE225,NVP-LDE225
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Smo
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	485.50
Product Description	Sonidegib (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Stem Cell/Wnt
Clinical information	Launched

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HY-16582A-10mM-safety-datasheet.pdf