« Back
Home /
Remodelin

Remodelin

Item no.	HY-16706-100mg
Manufacturer	MedChem Express
CASRN	949912-58-7
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 200 mg 25 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.79
Citations	[1]Larrieu D, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science. 2014 May 2;344(6183):527-32.\|[2]Ma N, et.al. Inhibition of N-Acetyltransferase 10 Suppresses the Progression of Prostate Cancer through Regulation of DNA Replication. Int J Mol Sci. 2022 Jun 12;23(12):6573. \|[3]Balmus G, et.al. Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome. Nat Commun. 2018 Apr 27;9(1):1700. \|[4]Zhang X, et.al. N-Acetyltransferase 10 Enhances Doxorubicin Resistance in Human Hepatocellular Carcinoma Cell Lines by Promoting the Epithelial-to-Mesenchymal Transition. Oxid Med Cell Longev. 2019 Jul 1;2019:7561879. bioRxiv. 2023 Feb 11.\|Cell Death Dis. 2023 Nov 1;14(11):712.\|Cell Rep. 2023 Jul 17;42(7):112810.\|J Agric Food Chem. 2021 Dec 23.\|J Virol. 2024 Jan 3:e0135023.\|Life Sci. 2023 Jul 17;121948.\|Acta Pharmacol Sin. 2023 Jun 5.\|Epigenetics. 2024 Dec;19(1):2417158.\|Heliyon. 2023 Jun 8.\|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.\|Oncogene. 2021 Apr;40(15):2711-2724.
Smiles	N#CC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	949912-58-7
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Histone Acetyltransferase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	282.36
Product Description	Remodelin is an orally active and selective inhibitor of acetyltransferase NAT10. Remodelin inhibits NAT10 activitity and slows DNA replication and suppresses growth of prostate cancer cells. Remodelin inhibits the growth of prostate cancer and hepatocellular carcinoma in xenograft model. Remodelin enhances the healthspan in hutchinson-gilford progeria syndrome (HGPS) mouse model[1][2][3][4].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 125 mg/mL (ultrasonic)
Manufacturer - Pathway	Epigenetics
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-16706-100mg-safety-datasheet.pdf