RO9021

Item no.	HY-16902-100mg
Manufacturer	MedChem Express
CASRN	1446790-62-0
Amount	100 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.88
Citations	[1]Liao C, et al. Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy.\|[2]Cheng Liao, et al. Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy.
Smiles	NC(C1=C(NC2=CC=C(C)C(C)=N2)C=C(N[C@H]3[C@@H](N)CCCC3)N=N1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1446790-62-0
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Syk
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	355.44
Product Description	RO9021 is an orally bioavailable, novel ATP-competitive inhibitor of SYK, with an average IC50 of 5.6 nM.
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 3.03 mg/mL (ultrasonic)
Manufacturer - Pathway	Protein Tyrosine Kinase/RTK
Clinical information	No Development Reported

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HY-16902-100mg-safety-datasheet.pdf