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JNJ 303

JNJ 303

Item no.	HY-16953-25mg
Manufacturer	MedChem Express
CASRN	878489-28-2
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Cardiovascular Research Ischemia & Reperfusion Injury Hypertension Inhibitors & Compound Libraries Small Molecules Arrhythmias
Type	Inhibitors
Specific against	other
Purity	98.74
Citations	[1]Julie Albrecht, et al. The effect of the KV7/KCNE 1 inhibitor JNJ 303 on heart slices and the L-type calcium channel of cardiac cells.\|[2]Zhaohuan Huang, et al. Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism. Sci Adv. 2022 Jun 10;8(23):eabn5345.
Smiles	ClC1=CC=C(OC(C)(C)C(N[C@@H]([C@@H](C2)C3)[C@@H]4C[C@H]2C[C@@]3(NS(=O)(C)=O)C4)=O)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	878489-28-2
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Potassium Channel
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	440.98
Product Description	JNJ-303 is a specific delayed rectifier Kv blocker. JNJ 303 can potent block IKs with an IC50 value of 64 nM. JNJ-303 can be used for the research of diabetes, obesity and central nervous system[1][2].
Manufacturer - Research Area	Neurological Disease; Cardiovascular Disease
Solubility	DMSO: 62.5 mg/mL (ultrasonic)
Manufacturer - Pathway	Membrane Transporter/Ion Channel
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-16953-25mg-safety-datasheet.pdf