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Genipin

Genipin

Item no.	HY-17389-50mg
Manufacturer	MedChem Express
CASRN	6902-77-8
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 25 mg 50 mg
Category	Oncology Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Neural Mitochondrial Function Regulation of Appetite Inhibitors & Compound Libraries Small Molecules By Organ Pancreatic Cancer
Type	Inhibitors
Specific against	other
Purity	99.55
Citations	[1]Ma C, et al. Genipin stimulates glucose transport in C2C12 myotubes via IRS-1 and calcium- dependent mechanism. J Endocrinol. 2012 Dec 20.\|[2]Kim BC, et al. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochem Pharmacol. 2005 Nov 1;70(9):1398-407.\|[3]Ye D, et al. Genipin normalizes depression-like behavior induced by prenatal stress through inhibiting DNMT1. Epigenetics. 2018 Mar 9:1-22.\|[4]Kim BC, et al. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochem Pharmacol. 2005 Nov 1;70(9):1398-407.
Smiles	O=C(C1=CO[C@@H](O)[C@@]2([H])[C@]1([H])CC=C2CO)OC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(+)-Genipin
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Autophagy
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	226.23
Product Description	Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research[1][2].
Manufacturer - Research Area	Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility	DMSO: ≥ 100 mg/mL\|H2O: 4 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy
Clinical information	Phase 3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-17389-50mg-safety-datasheet.pdf