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Amprenavir

Amprenavir

Item no.	HY-17430-50mg
Manufacturer	MedChem Express
CASRN	161814-49-9
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 25 mg 50 mg 5 mg
Category	Metabolism Cholesterol & Lipid Metabolism Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.55
Citations	[1]Sadler BM, Stein DS. Clinical pharmacology and pharmacokinetics of amprenavir. Ann Pharmacother. 2002 Jan;36(1):102-18.\|[2]Esposito V, Verdina A, Manente L, Amprenavir inhibits the migration in human hepatocarcinoma cell and the growth of xenografts. J Cell Physiol. 2013 Mar;228(3):640-5.\|[3]Helsley RN, Sui Y, Ai N, Pregnane X Receptor Mediates Dyslipidemia Induced by the HIV Protease Inhibitor Amprenavir in Mice. Mol Pharmacol. 2013 Jun;83(6):1190-9.\|[4]Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
Smiles	O=C(O[C@@H]1COCC1)N[C@@H](CC2=CC=CC=C2)[C@H](O)CN(S(=O)(C3=CC=C(N)C=C3)=O)CC(C)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	VX-478
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	HIV; HIV Protease; SARS-CoV
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	505.63
Product Description	Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM.
Manufacturer - Research Area	Infection; Cancer
Solubility	DMSO: ≥ 100 mg/mL
Manufacturer - Pathway	Anti-infection; Metabolic Enzyme/Protease
Clinical information	Launched

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HY-17430-50mg-safety-datasheet.pdf