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Salmeterol (xinafoate)

Salmeterol (xinafoate)

Item no.	HY-17453-10mM
Manufacturer	MedChem Express
CASRN	94749-08-3
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 200 mg 25 mg 50 mg 5 mg
Category	Neuroscience Metabolism Diabetes Glucose Homeostasis Neural Signaling Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.96
Citations	[1]Panayiotis A Procopiou, et al. The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group. Bioorg Med Chem. 2011 Oct 15;19(20):6026-32.\|[2]Malcolm Johnson. Effects of beta2-agonists on resident and infiltrating inflammatory cells. J Allergy Clin Immunol. 2002 Dec;110(6 Suppl):S282-90.\|[3]Zhiyuan Wang, et al. Efficacy of salmeterol and formoterol combination treatment in mice with chronic obstructive pulmonary disease. Exp Ther Med. 2018 Feb;15(2):1538-1545. Neurobiol Dis. 2020 Jul;140:104874.\|Cell Rep. 2019 Dec 3;29(10):2929-2935.e4\|Drug Test Anal. 2020 Aug 27.\|J Pharm Anal. 2024 Jan 4.\|J Pharmaceut Biomed. 2020, 113870.\|Nat Commun. 2020 Sep 25;11(1):4857.\|Neuron. 2024 Jul 25:S0896-6273(24)00494-X.
Smiles	O=C(C1=CC=C2C=CC=CC2=C1O)O.OC3=C(CO)C=C(C(CNCCCCCCOCCCCC4=CC=CC=C4)O)C=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GR 33343X xinafoate
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Adrenergic Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	603.75
Product Description	Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].
Manufacturer - Research Area	Inflammation/Immunology; Endocrinology
Solubility	DMSO: ≥ 50 mg/mL
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	β adrenergic receptor
Clinical information	Launched

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HY-17453-10mM-safety-datasheet.pdf