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Gossypol (acetic acid)

Gossypol (acetic acid)

Item no.	HY-17510-10mM
Manufacturer	MedChem Express
CASRN	12542-36-8
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 200 mg 500 mg 50 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Colorectal Cancer Lymphatic System Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.75
Formula	C32H34O10
Citations	Clin Transl Med. 2021 Jun;11(6):e467. Patent. US20220162561A1. Cancer Lett. 2019 Oct 1;461:31-43. Microb Pathog. 2024 Sep 21:106960. Transbound Emerg Dis. 2023 Nov 11. Nat Commun. 2023 Jun 10;14(1):3445. Patent. US20220162561A1. [1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.
Smiles	OC1=C(C2=C(O)C(C(C=O)=C(O)C(O)=C3C(C)C)=C3C=C2C)C(C)=CC4=C(C(C)C)C(O)=C(O)C(C=O)=C41.O=C(O)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(±)-Gossypol-acetic acid; BL-193 (acetic acid)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Bcl-2 Family
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	578.61
Product Description	Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
Manufacturer - Research Area	Cancer
Solubility	DMSO : 25 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis
Isoform	Bcl-2; Bcl-xL
Clinical information	Launched

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HY-17510-10mM-safety-datasheet.pdf