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Griseofulvin

Griseofulvin

Item no.	HY-17583-5g
Manufacturer	MedChem Express
CASRN	126-07-8
Amount	5 g
Quantity options	10 g 10 mM/1 mL 25 g 500 mg 5 g
Category	Cell Biology Cytoskeleton Inhibitors & Compound Libraries Small Molecules Mikrotubules
Type	Inhibitors
Specific against	other
Purity	99.05
Citations	[1]Brilhante RSN, et al. In vitro activity of azole derivatives and griseofulvin against planktonic and biofilm growth of clinical isolates of dermatophytes. Mycoses. 2018 Jul;61(7):449-454.\|[2]Schmeel LC, et al. Griseofulvin Efficiently Induces Apoptosis in In Vitro Treatment of Lymphoma and Multiple Myeloma. Anticancer Res. 2017 May;37(5):2289-2295.\|[3]Knasmüller S, et al. Toxic effects of griseofulvin: disease models, mechanisms, and risk assessment[J]. Critical reviews in toxicology, 1997, 27(5): 495-537.\|[4]BEDFORD C, et al. Studies on the biological disposition of griseofulvin, an oral antifungal agent[J]. AMA Archives of Dermatology, 1960, 81(5): 735-745.\|[5]Aldinger E E. Cardiovascular effects of griseofulvin[J]. Circulation Research, 1968, 22(5): 589-593.\|[6]Ho Y S, et al. Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells[J]. International journal of cancer, 2001, 91(3): 393-401.
Smiles	O=C1[C@]2(C(OC)=CC(C[C@H]2C)=O)OC3=C(Cl)C(OC)=CC(OC)=C13
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	126-07-8
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Antibiotic; Apoptosis; Bcl-2 Family; Caspase; Endogenous Metabolite; Fungal; Microtubule/Tubulin; Wee1
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	352.77
Product Description	Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome[1][2][3][4][5][6].
Manufacturer - Research Area	Cancer; Infection; Cardiovascular Disease
Solubility	DMSO: 33.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease
Isoform	Microbial Metabolite
Clinical information	Launched

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HY-17583-5g-safety-datasheet.pdf