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L-Thyroxine

L-Thyroxine

Item no.	HY-18341-1g
Manufacturer	MedChem Express
CASRN	51-48-9
Amount	1 g
Quantity options	10 mM/1 mL 1 g 500 mg
Category	Oncology Metabolism Cholesterol & Lipid Metabolism Inhibitors & Compound Libraries Small Molecules By Organ Thyroid Cancer
Type	Inhibitors
Specific against	other
Purity	99.49
Citations	[1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.\|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149. Cell Rep Med. 2023 May 24;101061.\|Dis Model Mech. 2024 Aug 14:dmm.050748.\|EMBO J. 2024 Jun 5.\|Mol Brain. 2021 Jan 27;14(1):25.\|Nat Immunol. 2024 Mar 18.\|Sci Rep. 2022 Jul 4;12(1):11259.\|Stem Cell Rev Rep. 2021 Jun;17(3):999-1013.\|J Drug Deliv Sci Technol. 2023 Sep 28, 105008.
Smiles	N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC(I)=C(O)C(I)=C2)C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Levothyroxine,T4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Targets	Endogenous Metabolite; Thyroid Hormone Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	776.87
Product Description	L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine, T3) from L-Thyroxine (T4)[1].
Manufacturer - Research Area	Endocrinology; Cancer
Solubility	1M NaOH: 5 mg/mL (ultrasonic; warming; adjust pH to 11 with NaOH; heat to 60°C)\|DMSO: 233.33 mg/mL (ultrasonic)\|H2O: < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Isoform	Human Endogenous Metabolite
Clinical information	Launched

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HY-18341-1g-safety-datasheet.pdf