TMPA

Manufacturer	MedChem Express
Category	Neuroscience Neuroinflammation Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	5 mg
Item no.	HY-18555-5mg
Targets	Others
CASRN	1258275-73-8
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPKα. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
MolecularWeight	380.48
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer; Metabolic Disease; Inflammation/Immunology
Solubility	DMSO : ≥ 100 mg/mL
Manufacturers Target	AMPK; Nuclear Hormone Receptor 4A/NR4A
Isoform	Nur77/NR4A1
Pathway	Epigenetics; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

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HY-18555-5mg-safety-datasheet.pdf