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PFI-2 (hydrochloride)

PFI-2 (hydrochloride)

Item no.	HY-18627A-10mg
Manufacturer	MedChem Express
CASRN	1627607-87-7
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Neuroscience Neural Epigenetics Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.48
Citations	[1]Yuzhen Niu, et al. Revealing inhibition difference between PFI-2 enantiomers against SETD7 by molecular dynamics simulations, binding free energy calculations and unbinding pathway analysis. Sci Rep. 2017 Apr 18;7:46547.\|[2]Benquan Liu, et al. Pharmacological inhibition of SETD7 by PFI-2 attenuates renal fibrosis following folic acid and obstruction injury. Eur J Pharmacol. 2021 Jun 15;901:174097. Diabetes. 2025 Feb 27:db240997.\|Int J Mol Med. 2021 Dec;48(6):210.\|Mol Carcinog. 2023 May 5.\|Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2961-2966. \|Research Square Print. September 20th, 2022.\|Acta Pharmacol Sin. 2021 Apr 13.\|Biochem Pharmacol. 2023 Dec 2:115964.\|Med Oncol. 2023 Apr 12;40(5):146.\|Patent. US20180263995A1.\|Sci Adv. 2023 May 26;9(21):eade4186.\|Sci Total Environ. 2022 Dec 5;861:160682.
Smiles	O=S(C1=CC2=C(CNCC2)C(F)=C1)(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)=O.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(R)-PFI-2 hydrochloride
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Histone Methyltransferase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	535.98
Product Description	PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R)-PFI-2 shows high inhibiting activity with IC50 value of 2.0 nM and (S)-PFI-2 shows inhibiting activity with IC50 value of 1.0 μM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis[1][2].
Manufacturer - Research Area	Cancer; Infection; Inflammation/Immunology
Solubility	DMSO: ≥ 32 mg/mL\|H2O: 5.56 mg/mL (ultrasonic)
Manufacturer - Pathway	Epigenetics
Isoform	SETD7/KMT7
Clinical information	No Development Reported

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HY-18627A-10mg-safety-datasheet.pdf