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Ro 48-8071

Ro 48-8071

Item no.	HY-18630-10mg
Manufacturer	MedChem Express
CASRN	161582-11-2
Amount	10 mg
Quantity options	100 mg 10 mg 1 ea 50 mg 5 mg
Category	Food Safety Hormones Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	ACS Synth Biol. 2023 Feb 28. Cancer Cell. 2023 May 23;S1535-6108(23)00142-3. Mol Cell. 2021 Jul 1;81(13):2736-2751.e8. Nat Commun. 2023 Jul 17;14(1):4267. Oncotarget. 2017 Feb 28;8(9):14860-14875. Sci China Life Sci. 2021 May 27;1-21. Cancer Res Commun. 2024 Jul 19. Cell Death Dis. 2021 May 13;12(5):482. Cell Death Discov. 2025 Feb 8;11(1):55. Cell Rep. 2022 Dec 13;41(11):111827. ImmunoMedicine. 2022 Dec. Mol Med Rep. 2021 Dec;24(6):828. [1]Morand OH, et al. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J Lipid Res. 1997 Feb;38(2):373-90. [2]Liang Y, et al. Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells. Onco Targets Ther. 2016 May 30;9:3223-32 [3]Liang Y, et al. Cholesterol biosynthesis inhibitors as potent novel anti-cancer agents: suppression of hormone-dependent breast cancer by the oxidosqualene cyclase inhibitor RO 48-8071. Breast Cancer Res Treat. 2014 Jul;146(1):51-62. [4]Chuang JC, et al. Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse. Biochem Pharmacol. 2014 Apr 1;88(3):351-63.
Smiles	O=C(C1=CC=C(Br)C=C1)C2=CC=C(OCCCCCCN(C)CC=C)C=C2F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	161582-11-2
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Estrogen Receptor/ERR
Shipping Temperature	Room temperature
Molecular Weight	448.37
Product Description	Ro 48-8071 is an inhibitor of OSC (Oxidosqualene cyclase) with IC50 of appr 6.5 nM.
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Apoptosis; Vitamin D Related/Nuclear Receptor
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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