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1400W (Dihydrochloride)

1400W (Dihydrochloride)

Item no.	HY-18731-10mM
Manufacturer	MedChem Express
CASRN	214358-33-5
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer
Type	Inhibitors
Specific against	other
Purity	99.94
Formula	C10H17Cl2N3
Citations	ACS Nano. 2025 Mar 2. Aging Cell. 2025 Feb 6:e14502. Biochem Biophys Res Commun. 2025 Jan 19:749:151345. Biomed Pharmacother. 2022 Jul;151:113098. Biomed Pharmacother. 2022 Sep;153:113532. Cell Metab. 2025 Jan 7;37(1):291-304.e9. Cell Rep. 2022 Feb 15;38(7):110391. Int J Biol Sci. 2020 Mar 5;16(9):1563-1574. Int J Ophthalmol. 2022 Jul 18;15(7):1053-1061. iScience. 2023 Jul 7. J Physiol. 2024 Jul 26. J Transl Med. 2023 Nov 25;21(1):852. Microvasc Res. 2022: 104468. Mol Cell. 2020 Jan 2;77(1):95-107.e5. Mucosal Immunol. 2024 Feb 20:S1933-0219(24)00015-1. Redox Biol. 2023 Sep 27, 102905. Sci Total Environ. 2020 Jan 1;698:134294. Skelet Muscle. 2022 Jul 29;12(1):19. bioRxiv. 2025 Feb 17. ISME J. 2024 Jan 28:wrae014. [1]Garvey EP, et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 1997 Feb 21;272(8):4959-63. [2]Shi Q, et al. 1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia. Behav Brain Res. 2017 Feb 15;319:188-199.
Smiles	CC(NCC1=CC=CC(CN)=C1)=N.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	214358-33-5
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; NO Synthase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	250.17
Product Description	1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation[1][2].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Cardiovascular Disease
Solubility	DMSO : 20 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Immunology/Inflammation
Isoform	iNOS
Clinical information	No Development Reported

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HY-18731-10mM-safety-datasheet.pdf