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L-NMMA (acetate)

L-NMMA (acetate)

Item no.	HY-18732A-100mg
Manufacturer	MedChem Express
CASRN	53308-83-1
Amount	100 mg
Quantity options	100 mg 10 mMx1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Neuroscience Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.0
Citations	[1]Frey C, et al. L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem. 1994 Oct 21;269(42):26083-91.\|[2]Maggi CA, et al. Effect of NG-monomethyl L-arginine (L-NMMA) and NG-nitro L-arginine (L-NOARG) on non-adrenergic non-cholinergic relaxation in the circular muscle of the human ileum. Br J Pharmacol. 1991 Aug;103(4):1970-2.\|[3]Nakamura T, et al. Effect of NG-monomethyl-L-arginine on arcade arterioles of rat spinotrapezius muscles. Am J Physiol. 1991 Jul;261(1 Pt 2):H46-52.
Smiles	N[C@@H](CCCNC(NC)=N)C(O)=O.O=C(C)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Tilarginine (acetate),Methylarginine (acetate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Endogenous Metabolite; NO Synthase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	248.28
Product Description	L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 μM, respectively.
Manufacturer - Research Area	Cardiovascular Disease; Cancer
Solubility	H2O: ≥ 50 mg/mL
Manufacturer - Pathway	Immunology/Inflammation; Metabolic Enzyme/Protease
Isoform	eNOS; iNOS; nNOS
Clinical information	Phase 4

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HY-18732A-100mg-safety-datasheet.pdf