G-5555

Item no.	HY-19635-25mg
Manufacturer	MedChem Express
CASRN	1648863-90-4
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 g 1 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Neuroscience Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.88
Citations	[1]Ndubaku CO, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6.\|[2]Rudolph J, et al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59(11):5520-41. Acta Pharm Sin B. 2020 Apr;10(4):603-614.\|Elife. 2017 Mar 13;6:e22207. \|Endocr Relat Cancer. 2019 Aug;26(8):699-712. \|Exp Hematol. 2023 Sep 21;S0301-472X(23)01701-0.\|PLoS One. 2024 Jul 31;19(7):e0305121.\|Research Square Preprint. 2021 Apr.\|Endocr Relat Cancer. 2019 Aug;26(8):699-712.
Smiles	ClC(C=C(C1=NC(C)=CC=C1)C=C2)=C2C3=CC4=CN=C(NC)N=C4N(C[C@@H]5OC[C@@H](N)CO5)C3=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1648863-90-4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	PAK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	492.96
Product Description	G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively.
Manufacturer - Research Area	Cancer
Solubility	DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Cytoskeleton
Clinical information	No Development Reported
Isoform	PAK1; PAK2

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HY-19635-25mg-safety-datasheet.pdf