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Danirixin

Danirixin

Item no.	HY-19768-1mg
Manufacturer	MedChem Express
CASRN	954126-98-8
Amount	1 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Neuroscience Neuroinflammation Metabolism Diabetes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.88
Citations	[1]Miller BE, et al. The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective CXCR2 antagonist?--in healthy adult subjects. BMC Pharmacol Toxicol. 2015 Jun 20;16:18.
Smiles	O=C(NC1=CC=C(Cl)C(S([C@H]2CCCNC2)(=O)=O)=C1O)NC3=C(C)C(F)=CC=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GSK1325756
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	CXCR
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	441.90
Product Description	Danirixin is a selective, and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8.
Manufacturer - Research Area	Inflammation/Immunology; Endocrinology
Solubility	DMSO: 8 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	GPCR/G Protein; Immunology/Inflammation
Isoform	CXCR2
Clinical information	Phase 2

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HY-19768-1mg-safety-datasheet.pdf