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Leucomethylene blue (mesylate)

Leucomethylene blue (mesylate)

Item no.	HY-19948-10mM
Manufacturer	MedChem Express
CASRN	1236208-20-0
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.75
Citations	[1]Gaudette NF, et al. Determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine andB6C3F1 mouse urine. J Anal Toxicol. 2005 Jan-Feb;29(1):28-33.\|[2]Zhenhua Liu, et al. Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A(1) receptor. Int J Mol Med. 2019 Jan;43(1):435-442.\|[3]Francesco Panza, et al. Tau aggregation inhibitors: the future of Alzheimer's pharmacotherapy? Expert Opin Pharmacother. 2016;17(4):457-61.
Smiles	CN(C)C1=CC(SC2=CC(N(C)C)=CC=C2N3)=C3C=C1.CS(=O)(O)=O.CS(=O)(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	TRx0237 (mesylate),Methylene blue leuco base (mesylate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Dye Reagents
Manufacturer - Targets	Tau Protein
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light, stored under nitrogen)
Molecular Weight	477.62
Product Description	Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes[1][2][3].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 110 mg/mL (ultrasonic)\|H2O: 83.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Neuronal Signaling
Clinical information	Phase 3

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HY-19948-10mM-safety-datasheet.pdf