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Clemizole

Clemizole

Item no.	HY-30234-50mg
Manufacturer	MedChem Express
CASRN	442-52-4
Amount	50 mg
Quantity options	100 mg 10 mg 1 ea 50 mg 5 mg
Category	Food Safety Histamines Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27 [2]Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21 [3]Nishimura T, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344(2):388-96.
Smiles	ClC1=CC=C(C=C1)CN2C(CN3CCCC3)=NC4=CC=CC=C24
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	442-52-4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	HCV; HCV Protease; Histamine Receptor; TRP Channel
Shipping Temperature	Room temperature
Molecular Weight	325.84
Product Description	Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. Clemizole is an inhibitor of TRPC5 channel. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 μM.
Manufacturer - Research Area	Cancer; Endocrinology; Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturer - Pathway	Anti-infection; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Isoform	H1 Receptor
Clinical information	Launched

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