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Secalciferol

Secalciferol

Item no.	HY-32343-5mg
Manufacturer	MedChem Express
CASRN	55721-11-4
Amount	5 mg
Quantity options	1 mg 5 mg
Category	Oncology Food Safety Hormones Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bladder Cancer Bone Cancer
Type	Inhibitors
Specific against	other
Purity	99.85
Citations	[1]Ono T, et al. 24R,25-dihydroxyvitamin D3 promotes bone formation without causing excessive resorption in hypophosphatemic mice[J]. Endocrinology. 1996 Jun;137(6):2633-7.\|[2]Higashi T, et al. In vitro and in vivo glucuronidation of 24,25-dihydroxyvitamin D3[J]. Steroids. 1999 Oct;64(10):715-25.\|[3]Bartonkova I, et al. Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24[J]. Chem Res Toxicol. 2016 Jul 18;29(7):1211-22.\|[4]Ikezaki S, et al. Influences of long-term administration of 24R, 25-dihydroxyvitamin D3, a vitamin D3 derivative, in rats[J]. J Toxicol Sci. 1999 May;24(2):133-9.
Smiles	C=C(CC1)/C(C[C@H]1O)=C\C=C2[C@@]3([H])[C@@](CCC\2)(C)[C@@H]([C@H](C)CC[C@@H](O)C(C)(C)O)CC3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(24R)-24,25-Dihydroxyvitamin D3
Shipping Condition	Cool pack
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Endogenous Metabolite; VD/VDR
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, protect from light, stored under nitrogen)
Molecular Weight	416.64
Product Description	Secalciferol ((24R)-24, 25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC50 value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders[1][2][3][4][5].
Manufacturer - Research Area	Metabolic Disease; Inflammation/Immunology
Solubility	DMSO: 100 mg/mL (ultrasonic)\|Ethanol: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Isoform	Human Endogenous Metabolite
Clinical information	No Development Reported

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HY-32343-5mg-safety-datasheet.pdf