Comparison

Deschloroclozapine European Partner

Item no. HY-42110-10mg
Manufacturer MedChem Express
CASRN 07.07.1977
Amount 10 mg
Quantity options 100 mg 10mM/1mL 10 mg 1 g 50 mg 5 g 5 mg
Category
Type Inhibitors
Specific against other
Purity 99.83
Formula C18H20N4
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[1]Maggs JL, et al. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. J Pharmacol Exp Ther. 1995;275(3):1463-1475.
[2]Hu F, et al. <sup>18</sup>F-labeled radiotracers for in vivo imaging of DREADD with positron emission tomography. Eur J Med Chem. 2021;213:113047.
[3]Upright NA, et al. Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates. Neuropsychopharmacology. 2020;45(11):1793-1798.
Smiles CN1CCN(C2=NC3=CC=CC=C3NC4=CC=CC=C42)CC1
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 07.07.1977
Shipping Condition Cool pack
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
Neuroscience-Neuromodulation
Manufacturer - Targets
mAChR
Shipping Temperature
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Molecular Weight
292.386
Product Description
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging[1][2][3].
Manufacturer - Research Area
Neurological Disease
Solubility
DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway
GPCR/G Protein; Neuronal Signaling
Isoform
mAChR3; mAChR4
Clinical information
No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 mg
Available: In stock
available

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