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Deschloroclozapine

Deschloroclozapine

Item no.	HY-42110-10mg
Manufacturer	MedChem Express
CASRN	1977-07-7
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 g 50 mg 5 g 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.93
Citations	[2]Hu F, et al. <sup>18</sup>F-labeled radiotracers for in vivo imaging of DREADD with positron emission tomography. Eur J Med Chem. 2021;213:113047.\|[3]Upright NA, et al. Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates. Neuropsychopharmacology. 2020;45(11):1793-1798.\|[1]Maggs JL, et al. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. J Pharmacol Exp Ther. 1995;275(3):1463-1475. ACS Pharmacol Transl Sci. 2025 Jun 6;8(7):2048-2060. Acta Neuropathol Commun. 2024 Nov 22;12(1):179. Behav Brain Funct. 2025 Nov 4;21(1):36. Behav Brain Res. 2023 Oct 18:455:114674. bioRxiv. 2020 May 18. bioRxiv. 2023 Apr 24. bioRxiv. 2023 Dec 22. bioRxiv. 2023 Jun 7:2023.06.06.543911. bioRxiv. 2023 Mar 6. bioRxiv. 2023 May 23. bioRxiv. 2023 Nov 17. bioRxiv. 2023 Nov 17:2023.11.17.567492. bioRxiv. 2023 Sep 15:2023.06.21.545778. bioRxiv. 2024 Feb 12:2024.02.12.579861. bioRxiv. 2024 July 02. bioRxiv. 2024 Jun 27:2024.06.22.600167. bioRxiv. 2024 Jun 28:2024.06.28.601172. bioRxiv. 2024 Mar 12:2024.03.09.584200. bioRxiv. 2024 November 03. bioRxiv. 2025 Aug 06. bioRxiv. 2025 Aug 07. bioRxiv. 2025 Jun 27:2025.06.26.661815. bioRxiv. 2025 Jun 8:2025.03.13.643119. bioRxiv. 2025 Oct 17. bioRxiv. July 19, 2021. bioRxiv. November 25, 2021. Cell Biol Toxicol. 2025 May 13;41(1):83. Cell Rep Methods. 2024 Oct 21;4(10):100881. Cell. 2023 Nov 22;186(24):5394-5410.e18. Cell. 2025 Oct 24:S0092-8674(25)01129-8. Curr Biol. 2025 Oct 29:S0960-9822(25)01311-9. eNeuro. 2023 Oct 24;10(10):ENEURO.0162-23.2023. eNeuro. 2025 Feb 7:ENEURO.0359-24.2025. Eur J Neurosci. 2023 Oct;58(8):3737-3750. Front Aging Neurosci. 2023 Mar 23:15:1142055. iScience. 2021 Aug 30;24(9):103066. IUBMB Life. 2024 Dec;76(12):1209-1222. J Cereb Blood Flow Metab. 2021 Oct;41(10):2571-2582. J Dig Dis. 2025 Jan-Feb;26(1-2):62-73. Nat Commun. 2022 Apr 25;13(1):2233. Nat Commun. 2022 Nov 4;13(1):6662. Nat Commun. 2023 Feb 24;14(1):1066. Nat Commun. 2023 Feb 28;14(1):971. Nat Commun. 2023 Jul 24;14(1):4456. Nat Commun. 2023 Oct 24;14(1):6758. Nat Neurosci. 2020 Sep;23(9):1157-1167. Nat Neurosci. 2025 Feb;28(2):320-335. Nature. 2025 Aug;644(8076):463-472. Nature. 2025 Jun;642(8067):411-420. Neuromethods. 2023 Feb 7. Neuron. 2021 Oct 20;109(20):3312-3322.e5. Neuron. 2022 Apr 20;110(8):1400-1415.e6. Neuron. 2024 Dec 4;112(23):3924-3939.e5. Neuropharmacology. 2023 Sep 1:235:109576. Neuropsychopharmacology. 2020 Oct;45(11):1793-1798. Neuropsychopharmacology. 2024 Dec;49(13):2022-2031. Patent. US20210275696A1. Res Sq. 2023 Mar 27:rs.3.rs-2729263. Research (Wash D C). 2025 May 14:8:0701. Research Square Preprint. 2023 Jul 24. Sci Adv. 2024 Jul 19;10(29):eadp5239. SSRN. 2025 Jun 20. University of British Columbia. 2025. University of Iowa. 2025. University of Utah. 2025. Adv Sci (Weinh). 2025 Apr;12(13):e2406192. bioRxiv. 2025 April 21. bioRxiv. 2025 May 02. bioRxiv. 2025 Oct 9. bioRxiv. 2025 Sep 6. The University of Chicago. 2023 Dec.
Smiles	CN1CCN(C2=NC3=CC=CC=C3NC4=CC=CC=C42)CC1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	07.07.1977
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Category	Reference compound / Active compounds
Manufacturer - Targets	mAChR
Manufacturer - HS Code	H302, H315, H319, H335
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	292.39
Product Description	Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging[1][2][3].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Clinical information	No Development Reported
Isoform	mAChR3; mAChR4
UNSPSC Code	12352005
Precautionary	H302, H315, H319, H335

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.