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Mavorixafor

Mavorixafor

Item no.	HY-50101-50mg
Manufacturer	MedChem Express
CASRN	558447-26-0
Amount	50 mg
Quantity options	100 mg 10 mMx1 mL 10 mg 1 ea 25 mg 2 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Neuroinflammation Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	95.0
Citations	[1]Skerlj RT, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53(8):3376-88.\|[2]Uchida D, et al. Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells. Oncol Rep. 2018 Jul;40(1):303-308. Biosci Rep. 2023 Dec 22;43(12):BSR20230981.\|Br J Haematol. 2022 Dec 19.\|Cell Mol Life Sci. 2024 Mar 13;81(1):132.\|Patent. US20220273751A1.\|PLoS One. 2016 Mar 21;11(3):e0151765.\|Am J Physiol Cell Physiol. 2025 Mar 10.\|Oncol Rep. 2022 Apr;47(4):68.\|Proc Natl Acad Sci U S A. 2025 Mar 18;122(11):e2425795122.
Smiles	NCCCCN(CC1=NC2=C(N1)C=CC=C2)[C@@H]3C4=C(CCC3)C=CC=N4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AMD-070,AMD-11070
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	CXCR; HIV
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, stored under nitrogen)
Molecular Weight	349.47
Product Description	Mavorixafor (AMD-070) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively. Mavorixafor can be used for the study of WHIM syndrome[1].
Manufacturer - Research Area	Infection; Endocrinology; Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Anti-infection; GPCR/G Protein; Immunology/Inflammation
Isoform	CXCR4; HIV-1
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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