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Perifosine

Perifosine

Item no.	HY-50909-10mM
Manufacturer	MedChem Express
CASRN	157716-52-4
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Oncology Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Skin Cancer
Type	Inhibitors
Specific against	other
Purity	99.91
Citations	[1]Momota H, et al. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res, 2005, 65(16), 7429-7435.\|[2]Vyomesh Patel, et al. Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest. Cancer Res, 2002, 62(5), 14\|[3]Chen L, et al. Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures. Epilepsia. 2012 Nov;53(11):2026-33.
Smiles	[O-]P(OC1CC[N+](C)(CC1)C)(OCCCCCCCCCCCCCCCCCC)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	KRX-0401,NSC 639966,D21266
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Akt; Apoptosis; Autophagy
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	461.66
Product Description	Perifosine is an oral Akt inhibitor which inhibits proliferation of different tumor cell lines with IC50s of 0.6-8.9 μM.
Manufacturer - Research Area	Cancer
Solubility	DMF: < 1 mg/mL\|DMSO: < 1 mg/mL\|H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; PI3K/Akt/mTOR
Clinical information	Phase 3

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HY-50909-10mM-safety-datasheet.pdf