AT7519

Item no.	HY-50940-100mg
Manufacturer	MedChem Express
CASRN	844442-38-2
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Lymphatic System Cancer Bone Cancer
Type	Inhibitors
Specific against	other
Purity	99.76
Formula	C16H17Cl2N5O2
Citations	Adv Sci (Weinh). 2024 Jan 6:e2305260. bioRxiv. 2024 September 07. Dev Biol. 2024 Jan 28:508:93-106. Exp Eye Res. 2023 Jan 22;227:109391. FASEB J. 2024 Apr 30;38(8):e23628. Glycobiology. 2022 Jun 16;cwac038. Harvard Medical School LINCS LIBRARY Oncogene. 2023 Oct 16. RNA Biol. 2021 Sep 30;1-8. Sci Rep. 2021 Mar 8;11(1):5374. Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. Cell Chem Biol. 2018 Feb 15;25(2):135-142.e5. Harvard Medical School LINCS LIBRARY [1]Santo L, et al. AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition. Oncogene. 2010 Apr 22;29(16):2325-36. [2]Squires MS, et al. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. [3]Squires MS, et al. AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples. Mol Cancer Ther. 2010 Apr;9(4):920-8.
Smiles	O=C(NC1=CNN=C1C(NC2CCNCC2)=O)C3=C(Cl)C=CC=C3Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AT7519M
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; CDK
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	382.24448
Product Description	AT7519 (AT7519M) as a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.
Manufacturer - Research Area	Cancer
Solubility	DMSO : ≥ 50 mg/mL
Manufacturer - Pathway	Apoptosis; Cell Cycle/DNA Damage
Isoform	CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9
Clinical information	Phase 2

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HY-50940-100mg-safety-datasheet.pdf