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AT7519 (Hydrochloride)

AT7519 (Hydrochloride)

Item no.	HY-50943-10mg
Manufacturer	MedChem Express
CASRN	902135-91-5
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Lymphatic System Cancer Bone Cancer
Type	Inhibitors
Specific against	other
Purity	99.42
Formula	C16H18Cl3N5O2
Citations	Cell Chem Biol. 2018 Feb 15;25(2):135-142.e5. Harvard Medical School LINCS LIBRARY Adv Sci (Weinh). 2024 Jan 6:e2305260. bioRxiv. 2024 September 07. Dev Biol. 2024 Jan 28:508:93-106. Exp Eye Res. 2023 Jan 22;227:109391. FASEB J. 2024 Apr 30;38(8):e23628. Glycobiology. 2022 Jun 16;cwac038. Harvard Medical School LINCS LIBRARY Oncogene. 2023 Oct 16. RNA Biol. 2021 Sep 30;1-8. Sci Rep. 2021 Mar 8;11(1):5374. Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. [1]Santo L, et al. AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition. Oncogene. 2010 Apr 22;29(16):2325-36. [2]Squires MS, et al. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. [3]Squires MS, et al. AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples. Mol Cancer Ther. 2010 Apr;9(4):920-8.
Smiles	O=C(C(C(Cl)=CC=C1)=C1Cl)NC2=CNN=C2C(NC3CCNCC3)=O.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	902135-91-5
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; CDK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	418.71
Product Description	AT7519 Hydrochloride is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.
Manufacturer - Research Area	Cancer
Solubility	DMSO : ≥ 300 mg/mL\|H2O : 8.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Cell Cycle/DNA Damage
Isoform	CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9
Clinical information	Phase 2

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HY-50943-10mg-safety-datasheet.pdf