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Cinacalcet

Cinacalcet

Item no.	HY-70037-10mg
Manufacturer	MedChem Express
CASRN	226256-56-0
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Thyroid Cancer
Type	Inhibitors
Specific against	other
Purity	99.93
Citations	[1]Colloton M, et al. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int. 2005 Feb;67(2):467-76.\|[2]D.A. Bushinsky, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69(9):1586-92. Acta Physiol. 2023 Jan 6;e13926.\|Calcif Tissue Int. 2023 Feb 8.\|Cell Biol Toxicol. 2022 May 30.\|Gen Comp Endocrinol. 2018 Oct 1;267:1-8.\|J Agric Food Chem. 2021 Nov 8.\|J Biol Chem. 2016 Oct 28;291(44):23126-23135.\|J Clin Endocrinol Metab. 2024 Oct 16:dgae735.\|J Food Sci. 2018 Sep;83(9):2394-2401.\|J Med Chem. 2015 Apr 9;58(7):2958-66. \|Oxid Med Cell Longev. 2017;2017:3869561.\|Oxid Med Cell Longev. 2021 Jan 12;2021:3010548.\|Adv Mater. 2024 Jun;36(24):e2311760.\|Cell Rep Methods. 2023 Oct 23;3(10):100599.\|iScience. 2023 Mar.\|Patent. US20230147129A1.
Smiles	FC(F)(C1=CC(CCCN[C@@H](C2=C3C=CC=CC3=CC=C2)C)=CC=C1)F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AMG 073
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	CaSR; Endogenous Metabolite
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	357.41
Product Description	Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease research.
Manufacturer - Research Area	Cardiovascular Disease; Cancer
Solubility	DMSO: ≥ 100 mg/mL
Manufacturer - Pathway	GPCR/G Protein; Metabolic Enzyme/Protease
Clinical information	Launched

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HY-70037-10mg-safety-datasheet.pdf