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SB-408124

SB-408124

Item no.	HY-70068-100mg
Manufacturer	MedChem Express
CASRN	288150-92-5
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 5 mg
Category	Food Safety Histamines Neuroscience Neural Lineage Markers Metabolism Glucose Homeostasis Regulation of Appetite Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.27
Formula	C19H18F2N4O
Citations	[1]Langmead CJ, et al. Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br J Pharmacol. 2004;141(2):340-346. [2]Kis GK, et al. The osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats. Pflugers Arch. 2012;463(4):531-536.
Smiles	O=C(NC1=CC(C)=NC2=C(C=C(C=C21)F)F)NC3=CC=C(C=C3)N(C)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	288150-92-5
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Orexin Receptor (OX Receptor)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	356.3692264
Product Description	SB-408124 is a non-peptide OX1 receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor[1].
Manufacturer - Research Area	Neurological Disease; Endocrinology
Solubility	DMSO : 50 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	OX1 Receptor
Clinical information	No Development Reported

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HY-70068-100mg-safety-datasheet.pdf