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Furagin

Furagin

Item no.	HY-77036-1g
Manufacturer	MedChem Express
CASRN	1672-88-4
Amount	1 g
Quantity options	10 mM/1 mL 1 g 500 mg 5 g
Category	Food Safety Antibiotics Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.84
Citations	[1]Mannisto P, et al. Pharmacokinetics of furagin, a new nitrofurantoin congener, on human volunteers. Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):264-70.\|[2]Slapsyte G, et al. Cytogenetic analysis of children under long-term antibacterial therapy with nitroheterocyclic compound furagin. Mutat Res. 2001 Apr 5;491(1-2):25-30.\|[3]Pustenko A, et al. The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1011-1020.\|[4]Osterman IA, et al. Sorting Out Antibiotics' Mechanisms of Action: a Double Fluorescent Protein Reporter for High-Throughput Screening of Ribosome and DNA Biosynthesis Inhibitors[J]. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7481-7489.\|[5]Sapegin A, et al. Novel 5-Nitrofuran-Tagged Imidazo-Fused Azines and Azoles Amenable by the Groebke-Blackburn-Bienaymé Multicomponent Reaction: Activity Profile against ESKAPE Pathogens and Mycobacteria. Biomedicines. 2022 Sep 6;10(9):2203.
Smiles	O=C1NC(CN1/N=C/C=C/C2=CC=C(O2)[N+]([O-])=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Furazidine,Furazidin
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Antibiotic; Bacterial; Carbonic Anhydrase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	264.19
Product Description	Furagin (Furazidine), an analogue of Nitrofurantoin (HY-A0090), is an antibiotic with antibacterial activity against ESKAPE pathogens with MIC values of 0-32 µg/mL. Furagin inhibits human Carbonic anhydrases . Furagin is promising for research of cancer and urinary tract infections (UTIs)[1][2][3][4][5].
Manufacturer - Research Area	Cancer; Infection
Solubility	DMSO: 25 mg/mL (ultrasonic)\|H2O: < 0.1 mg/mL
Manufacturer - Pathway	Anti-infection; Metabolic Enzyme/Protease
Isoform	CA IX; CA XII
Clinical information	Launched

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HY-77036-1g-safety-datasheet.pdf