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Lenalidomide (hemihydrate)

Lenalidomide (hemihydrate)

Manufacturer	MedChem Express
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Neural Development Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer Lymphatic System Cancer Bone Cancer
Type	Inhibitors
Specific against	other
Clone	N/A
Amount	100 mg
Item no.	HY-A0003B-100mg
Targets	Ligands for E3 Ligase; Molecular Glues; Apoptosis
CASRN	847871-99-2
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	Lenalidomide hemihydrate (CC-5013 hemihydrate), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hemihydrate is an orally active immunomodulator. Lenalidomide hemihydrate (CC-5013 hemihydrate) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide hemihydrate (CC-5013 hemihydrate) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	268.27
Clinical_Information	Launched
Manufacturers Research_Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL
Manufacturers Target	Apoptosis; Ligands for E3 Ligase; Molecular Glues
Isoform	Cereblon
Pathway	Apoptosis; PROTAC
Manufacturers Product type	Reference compound

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HY-A0003B-100mg-safety-datasheet.pdf