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Liothyronine (sodium)

Liothyronine (sodium)

Item no.	HY-A0070-500mg
Manufacturer	MedChem Express
CASRN	55-06-1
Amount	500 mg
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Thyroid Cancer
Type	Inhibitors
Specific against	other
Purity	99.35
Citations	[1]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.\|[2]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.\|[3]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34. bioRxiv. 2024 November 15.\|J Ethnopharmacol. 2022 Aug 11;115622.\|JCI Insight. 2021 Jun 22;6(12):142838.\|Sci Adv. 2024 Feb 9;10(6):eadk3931.\|Acta Pharmacol Sin. 2024 May 24.\|Adipocyte. 2022 Dec;11(1):84-98.\|Adv Healthc Mater. 2025 Feb 28:e2404388.\|Am J Physiol Endocrinol Metab. 2024 Apr 3.\|Cell Death Discov. 2022 Apr 30;8(1):236.\|Cell Metab. 2023 Sep 7;S1550-4131(23)00304-2.\|Cell Rep. 2024 Mar 18;43(3):113930.\|Chem Eng J. 2024 Sep 15.\|Environ Sci Technol. 2025 Feb 27.\|Eur J Med Chem. 2024 Mar 20:269:116344.\|Food Science and Human Wellness. 2023 Nov;12(6);2061-2072.\|J Med Chem. 2022 Jan 21.\|J Nutr Biochem. 2020 Apr;78:108335.\|J Therm Biol. 2024 Jul 2:123:103906.\|Methods Mol Biol. 2023;2683:103-111.\|Mol Metab. 2024 Oct 29:102053.\|Mol Metab. 2025 Mar 19:102125.\|Nat Commun. 2023 Jun 2;14(1):3208.\|Patent. US20220389379A1.\|Sci Rep. 2024 Sep 2;14(1):20370.
Smiles	N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(O)C(I)=C2)C(O[Na])=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Triiodothyronine (sodium),3,3',5-Triiodo-L-thyronine (sodium),T3 (sodium)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Endogenous Metabolite; Thyroid Hormone Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	672.96
Product Description	Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].
Manufacturer - Research Area	Cancer; Endocrinology
Solubility	DMSO: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Isoform	Human Endogenous Metabolite
Clinical information	Launched

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HY-A0070-500mg-safety-datasheet.pdf