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Sapropterin (dihydrochloride)

Sapropterin (dihydrochloride)

Item no.	HY-A0124A-10mg
Manufacturer	MedChem Express
CASRN	69056-38-8
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.89
Formula	C9H17Cl2N5O3
Citations	[1]Sanford M, et al. Sapropterin: a review of its use in the treatment of primary hyperphenylalaninaemia. Drugs. 2009;69(4):461-76. [2]Schmitz K, et al. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics. 2021 Jul;18(3):1862-1879.
Smiles	O=C1N=C(N)NC2=C1N[C@@H]([C@@H](O)[C@@H](O)C)CN2.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(6R)-BH4 (dihydrochloride), (6R)-Tetrahydro-L-biopterin (dihydrochloride)
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Others
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, stored under nitrogen, away from moisture)
Molecular Weight	314.17
Product Description	Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin also drives autoimmunity. Sapropterin can be used in study of phenylketonuria (PKU)[1][2].
Manufacturer - Research Area	Metabolic Disease; Inflammation/Immunology
Solubility	DMSO : ≥ 200 mg/mL\|H2O : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Others
Clinical information	Launched

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HY-A0124A-10mg-safety-datasheet.pdf