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Histamine (phosphate)

Histamine (phosphate)

Item no.	HY-A0129-10mM
Manufacturer	MedChem Express
CASRN	51-74-1
Amount	10 mM/1 mL
Quantity options	10 mM/1 mL 1 g 500 mg
Category	Food Safety Histamines Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.34
Citations	[1]Okabe S, et al. Effects of cimetidine, a histamine H2-receptor antagonist, on various experimental gastric and duodenal ulcers. Am J Dig Dis. 1977 Aug;22(8):677-84. \|[2]Rietveld S et al. The influence of respiratory sounds on breathlessness in children with asthma: a symptom-perceptionapproach. Health Psychol. 1997 Nov;16(6):547-53. \|[3]Malmberg-Aiello P, et al., Role of histamine in rodent antinociception. Br J Pharmacol. 1994 Apr;111(4):1269-79. \|[4]Medina V, et al., Histamine-mediated signaling processes in human malignant mammary cells. Cancer Biol Ther. 2006 Nov;5(11):1462-71.\|[5]Ferreira R, et al., Histamine modulates microglia function. J Neuroinflammation. 2012 May 8;9:90. \|[6]MARTIN L. The effects of histamine on the vaginal epithelium of the mouse. J Endocrinol. 1962 Jan;23:329-40. \|[7]Yang LP, et al. Spotlight on histamine dihydrochloride in acute myeloid leukaemia. Drugs Aging. 2011 Apr 1;28(4):325-9. Insect Sci. 2025 Sep 11. JID Innov. 2025 Apr 3;5(4):100369. Adv Sci (Weinh). 2023 Mar;10(7):e2203869. Biochem Biophys Res Commun. 2025 Apr 1:755:151566. Biol Pharm Bull. 2023;46(6):864-868. bioRxiv. 2024 June 12. Br J Pharmacol. 2021 Apr;178(7):1669-1683. Cancer Cell. 2022 Oct 10;40(10):1111-1127.e9. FASEB J. 2025 Jul 15;39(13):e70778. Fishes. 2025 Aug 14. Front Pharmacol. 2019 Nov 15;10:1380. J Agric Food Chem. 2025 Nov 19;73(46):29604-29618. J Cell Commun Signal. 2023 Mar;17(1):151-165. Microbiol Spectr. 2023 Jan 31;11(2):e0469822. Pharm Res. 2025 Aug;42(8):1315-1329. Immunity. 2025 Aug 12:S1074-7613(25)00314-0. mBio. 2022 Oct 26;13(5):e0200422.
Smiles	NCCC1=CNC=N1.O=P(O)(O)O.O=P(O)(O)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Histamine diphosphate
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Category	Reference compound / Active compounds; API; Natural Products
Manufacturer - Targets	Akt; Apoptosis; Endogenous Metabolite; Histamine Receptor; p38 MAPK; Reactive Oxygen Species (ROS)
Manufacturer - HS Code	H302, H315, H317, H318, H334, H335
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	307.14
Product Description	Histamine phosphate is the agonist for histamine receptor and a vasodilator. Histamine phosphate is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine phosphate affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine phosphate can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma[1][2][3][4][5][6][7].
Manufacturer - Research Area	Cancer; Endocrinology; Inflammation/Immunology; Neurological Disease
Solubility	DMSO : 1.43 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR
Clinical information	Launched
UNSPSC Code	12352005
Precautionary	H302, H315, H317, H318, H334, H335

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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