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Ondansetron (hydrochloride dihydrate)

Ondansetron (hydrochloride dihydrate)

Item no.	HY-B0002A-10mM
Manufacturer	MedChem Express
CASRN	103639-04-9
Amount	10 mMx1 mL
Quantity options	100 mg 10 mMx1 mL 1 g 50 mg 5 g
Category	Metabolism Regulation of Appetite Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.94
Citations	[1]Yamamoto K, et al. Ondansetron, dexamethasone and an NK1 antagonist block radiation sickness in mice. Pharmacol Biochem Behav. 2005 Sep;82(1):24-9. \|[2]Wilde MI, et al. Ondansetron. A review of its pharmacology and preliminary clinical findings in novel applications. Drugs. 1996 Nov;52(5):773-94. Eur J Pharm Sci. 2023 May 22;106475.\|Int J Pharm. 2015 Dec 30;496(1):33-41.\|Patent. US20170319486A1.\|Front Pharmacol. 2024 Aug 21:15:1443169.\|J Ethnopharmacol. 2024 Jan 5:117703.\|J Radiat Res Appl Sci. 2023 Dec, 16(4), 100682.\|Prog Neuropsychopharmacol Biol Psychiatry. 2022 Nov 30;110689.\|SSRN. 2023 Srep 5.
Smiles	O=C1C(CN2C=CN=C2C)CCC(N3C)=C1C4=C3C=CC=C4.[H]Cl.O.O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GR 38032 (hydrochloride dihydrate),SN 307 (hydrochloride dihydrate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	5-HT Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	365.85
Product Description	Ondansetron (GR 38032; SN 307) hydrochloride dehydrate is a highly selective 5-HT3 receptor antagonist with an IC50 value of 103 pM. Ondansetron hydrochloride dehydrate exerts its antiemetic effect by antagonizing 5-HT receptors located in localized neurons in the peripheral and central nervous systems. Ondansetron hydrochloride dehydrate can inhibit nausea and vomiting induced by chemotherapy and radiotherapy[1][2][3][4][5][6][7][8].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 16.67 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Clinical information	Launched
Isoform	lactoferrin

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HY-B0002A-10mM-safety-datasheet.pdf