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Lurasidone (Hydrochloride)

Lurasidone (Hydrochloride)

Item no.	HY-B0032-500mg
Manufacturer	MedChem Express
CASRN	367514-88-3
Amount	500 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 200 mg 500 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules Neuronal Cell Markers
Type	Inhibitors
Specific against	other
Purity	99.96
Citations	[1]Ishibashi T, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010 Jul;334(1):171-81.\|[2]Sakine Atila Karaca, et al. Development of a validated high-performance liquid chromatographic method for the determination of Lurasidone in pharmaceuticals. Marmara Pharm J. 2017;21 (4): 931-937. ACS Chem Neurosci. 2020 Jan 15;11(2):173-183.\|Marmara Pharm J. 2017;21 (4): 931-937.\|Antibiotics (Basel). 2024 Mar 28, 13(4), 308.\|bioRxiv. 2024 Jan 14.\|J Med Chem. 2024 Apr 25;67(8):6144-6188.\|J Ocul Pharmacol Ther. 2024 Aug 29.\|Marmara Pharm J. 2017;21 (4): 931-937.\|Marmara Pharm J. 2017;21 (4): 931-937.\|Nature. 2023 Dec;624(7992):672-681.
Smiles	O=C([C@H]([C@H]1CC[C@@H]2C1)[C@H]2C3=O)N3C[C@@H]4CCCC[C@H]4CN(CC5)CCN5C6=NSC7=CC=CC=C76.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SM-13496 (Hydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	5-HT Receptor; Dopamine Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	529.14
Product Description	Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 6.67 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 80°C)\|Ethanol: 2 mg/mL (ultrasonic)\|H2O: < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	5-HT1 Receptor; 5-HT7 Receptor; D2 Receptor; mLAG-3; MUC3
Clinical information	Launched

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HY-B0032-500mg-safety-datasheet.pdf